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The Savant SpeedVac SPD140DDA modular vacuum concentrator from Thermo Scientific is an industrial strength deluxe modular benchtop concentrator. It is specifically designed for highly aggressive solvents such as DMSO, methylene chloride (DCM), TFA, strong acids and strong bases. As a result, the system processes solvents that no other medium capacity SpeedVac can handle.
Firstly, the SPD140DDA is the heaviest medium capacity SpeedVac model in the Thermo Scientific range. As a result, you process solvents that the SPD120 and SPD130DLX cannot handle. For example, DMSO, methylene chloride, TFA, strong acids, strong bases, DMF, benzene, nitrobenzene, pentane and toluene. Moreover, this is the only medium capacity model recommended by Thermo for solid phase synthesis cleavage solutions.
Firstly, the SPD140DDA features an extensive chemical resistance package. It contains a rugged stainless steel magnetic drive, lubricated with acid-resistant grease. In addition, the system contains acid-resistant TEFLON bearings that withstand acids over the long term. Moreover, all components in the vapor path are made of PTFE or PTFE-coated materials. Finally, the dual valve manifold ensures that solvent vapor has minimal contact with other parts. As a result, the unit retains its integrity even after prolonged use with aggressive chemicals.
Firstly, the main difference from the SPD130DLX is the extensive heating setup. The SPD140DDA features 2 built-in chamber radiant lamps, positioned for optimal evaporation. In addition, the heated glass cover adds extra radiant heat. Moreover, the heated cover prevents condensation of DMSO on the glass, which is a common problem with high-boiling solvents. As a result, drying times remain consistent, even with difficult solvents.
Firstly, a distinguishing feature is the adjustable vacuum ramp. Subsequently, you set the speed at which vacuum is built up at 5 levels: 5, 30, 40, 50 or 70 Torr/min. As a result, you prevent bumping with low-boiling solvents and optimize drying times with high-boiling solvents. Moreover, you combine this ramp control with the vacuum level setting from 20 to 0.1 Torr in 0.1 increments. In this way, you have full control over the drying process.
Firstly, the SPD140DDA offers 4 preset programs plus 8 user-defined programs. As a result, this is the most extensive program package of all medium capacity SpeedVacs. The preset programs are: Water (45°C, 14 Torr, ramp 5), Low Boiling ACN/MEOH (45°C, 100 mTorr, ramp 5), HPLC (no heating, 10 Torr, ramp 5) and High Boiling Solvents (65°C, 100 mTorr, ramp 5) for acetic acid, isopropanol, toluene, DMSO and TFA. In addition, you configure 8 of your own programs for your specific workflows.
Firstly, the SPD140DDA accepts by far the broadest range of solvents of all SpeedVacs. For example, DMSO, DMF, methylene chloride (DCM), TFA, HCl, strong acids and bases. In addition, the system processes all solvents that the SPD130DLX and SPD120 can handle. Moreover, the SPD140DDA works with benzene, butanol, chloroform, cyclohexane, ethyl ether, n-hexane, n-heptane, isopropanol, methanol, nitrobenzene, pentane, petroleum ether, pyridine and toluene. Finally, the system is suitable for combinatorial chemistry solvents and synthesis solids.
Firstly, Thermo Scientific recommends three system configurations depending on your solvents. The first option is the UVS850DDA Universal Vacuum System for volatile low-boiling solvents (DCM), corrosive solvents (TFA) and small quantities of DMSO and DMF. Secondly, the RVT450 + VLP80DDA setup for large volumes of high-boiling solvents such as DMSO and DMF. Thirdly, the RVT5105 + VLP80DDA setup for large volumes of low-boiling solvents. In addition, for all types of solvents you choose the complete combination RVT450 + RVT5105 + VLP80DDA.
Firstly, for pure DMSO applications Thermo offers a dedicated Low Vacuum System (LVS140DDA) configuration. In this setup, you combine the SPD140DDA with RVT450, RVT5105 and the OFP400 oil-free vacuum pump. As a result, you process DMSO efficiently without oil contamination. Moreover, this is optimized at the right vacuum level for this specific solvent.
Firstly, the SPD140DDA continuously monitors the vacuum through a built-in digital vacuum gauge. As a result, you set the vacuum level from 20 to 0.1 Torr in 0.1 Torr increments. Moreover, the vacuum is displayed in both Torr and milliTorr. Finally, the display shows “HPr” when the chamber is at atmospheric pressure, for clear status information.
Firstly, the SPD140DDA exports live run data every minute via the USB type A/B port. Subsequently, you receive chamber temperature, remaining heat time, run time and vacuum value in CSV format at 115200 baud. As a result, you easily meet GMP and GLP reporting requirements for pharmaceutical and biotech applications.
Firstly, the SPD140DDA is supplied as standard with an attached SUMAX SPD upper magnetic assembly. This magnetic assembly enables the high-quality magnetic drive coupling. Moreover, it requires maintenance every two weeks, depending on usage. The maintenance is a straightforward procedure: remove the assembly, rinse under tap water, dry and reinstall. As a result, the instrument continues to perform optimally during intensive use with aggressive solvents.
Firstly, the SPD140DDA is available in three configurations. The first is the standalone concentrator unit with attached SUMAX SPD upper magnetic assembly and TEFLON tubing (1/2″ I.D. × 90 cm). Secondly, the P1 kit for Semi-Integrated System with UVS850DDA Universal Vacuum System, ANT100 post-trap and rotor. Thirdly, the complete P2 kit for Component High Vacuum System with separate cold trap, VLP80DDA high vacuum pump, DVG50 vacuum gauge, VPOF110 oil filter, rotor and accessories.
Firstly, the SPD140DDA is used for combinatorial chemistry, medicinal chemistry, drug discovery, peptide synthesis, organic synthesis and the pharmaceutical industry. Typical applications include solid phase synthesis cleavage, protein hydrolyzates, evaporating synthesis solids, evaporating dissolution solvents, library purification, HPLC fractions with aggressive solvents and residue analysis. Would you like advice on the right SpeedVac for your application? Contact us and our product specialists will be glad to help.
| Property | Value |
|---|---|
| Model | SPD140DDA-230 |
| System type | Modular DDA (Dual Direct Aggressive) industrial strength for aggressive solvents |
| Capacity | Up to 120 × 1.5-2.0 mL microtubes (RH120-11 rotor), or 6 × 50 mL conical tubes (RH6-50) |
| Dimensions (W × D × H) | 36 × 46 × 36 cm |
| Weight | 28 kg |
| Chamber material | PTFE (TEFLON)-coated chemical resistant aluminum casting with 2 built-in radiant lamps |
| Vapor path materials | PTFE and PTFE-coated materials (exclusively in vapor path) |
| Bearings | Acid-resistant TEFLON bearings |
| Magnetic drive | Rugged stainless steel with acid-resistant grease |
| Magnetic assembly | SUMAX SPD upper magnetic assembly (included as standard) |
| Tubing | PTFE (1/2″ I.D. × 90 cm) included |
| Cover | Heated glass cover with safety interlock (prevents DMSO condensation) |
| Radiant lamps | 2 built into chamber + heated cover |
| Dual valve manifold | Yes (for minimal vapor exposure) |
| Lid-stay mechanism | Yes |
| Temperature range | 35-80°C in 5°C increments, or “no” for no heating |
| Pre-heat function | 45°C |
| Vacuum level setting | 20 to 0.1 Torr in 0.1 increments |
| Vacuum ramp setting | 5 levels: 5, 30, 40, 50 or 70 Torr/min |
| Vacuum gauge | Built-in digital vacuum gauge (Torr and milliTorr) |
| Run types | Manual Run and Auto Run (time-based) |
| Programs | 4 preset (Water, Low Boiling ACN/MEOH, HPLC, High Boiling Solvents) + 8 user-defined (modifiable and storable) |
| Timer range | 2 independent timers: 1 minute to 9 hours 59 minutes, or continuous (CCC) for heat time |
| Operating modes | Auto Run, Manual Run, Pre-heat, RL On/Off (radiant lamp), Vacuum Type (Level/Ramp) |
| Data export | USB type A/B port, 115200 baud, CSV format (temperature, heat time, run time, vacuum pressure) |
| Power supply | 230 VAC / 50 Hz, 3 amperes |
| Fuse | 3 A, 250 VAC, Time-lag |
| Induction motor | Maintenance-free |
| Compatible solvents | DMSO, DMF, DCM, TFA, HCl, acetone, acetic acid, ammonium hydroxide, benzene, butanol, n-butanol, chloroform, cyclohexane, ethyl acetate, ethanol, ethyl ether, n-hexane, n-heptane, isopropanol, isobutanol, methanol, methylene chloride, nitrobenzene, pentane, petroleum ether, n-propanol, propanol-1, pyridine, toluene, and all non-aggressive solvents |
| Specific approval | Combinatorial chemistry |
| P1 kit cold trap | UVS850DDA with ANT100 post-trap |
| P2 kit components | RVT450 + RVT5105 + VLP80DDA + DVG50 + VPOF110 |
| DMSO setup | LVS140DDA (RVT450 + RVT5105 + OFP400 oil-free pump) |
| Audible notifications | Yes (5 beeps startup, 1 beep run start, 3 beeps stop, error tones) |
| Emergency cover release | Yes |
| SUMAX SPD maintenance | Every 2 weeks (depending on usage) |
| Certification | UL listed (US/Canada), CE |
| Required ventilation space | 10 cm (4 inch) on all sides, 46 cm (18 inch) overhead for cover opening |
| Included (standard) | SPD140DDA concentrator with SUMAX SPD, PTFE tubing (1/2″ × 90 cm), power cord |
| Recommended additions | UVS850DDA, RVT450/RVT5105, VLP80DDA pump (see configurations) |
Industrial strength modular SpeedVac vacuum concentrator for highly aggressive solvents. Resistant to DMSO, methylene chloride, TFA, strong acids and bases thanks to stainless steel magnetic drive, acid-resistant TEFLON bearings and PTFE vapor path. Medium capacity up to 120 microtubes, 2 built-in radiant lamps plus heated cover, vacuum ramp control and 12 programs. Available as standalone unit, Semi-Integrated kit (P1) or Component High Vacuum kit (P2).
The SPD140DDA is used for concentrating and drying samples in highly aggressive solvents. Typical applications include combinatorial chemistry, solid phase synthesis cleavage, protein hydrolyzates, evaporating synthesis solids, peptide synthesis, library purification and HPLC fractions with TFA, DMSO, DCM or strong acids and bases.
Both are modular medium capacity SpeedVacs with radiant lamps and built-in digital vacuum gauge. However, the main difference is the industrial strength execution of the SPD140DDA. Firstly, the SPD140DDA features a stainless steel magnetic drive with acid-resistant grease and acid-resistant TEFLON bearings. Secondly, the instrument has 2 built-in chamber radiant lamps plus a heated cover that prevents DMSO condensation. Moreover, the SPD140DDA offers 12 programs (4 preset + 8 user-defined) compared to 6 on the SPD130DLX. Finally, the SPD140DDA handles more aggressive solvents such as DMSO, DMF, methylene chloride and strong acids and bases that the SPD130DLX cannot process.
The SPD140DDA processes the broadest range of solvents of all medium capacity SpeedVacs. For example, DMSO, DMF, methylene chloride (DCM), trifluoroacetic acid (TFA), HCl, strong acids and bases, benzene, toluene, nitrobenzene and pentane. In addition, the system accepts acetone, chloroform, cyclohexane, ethyl ether, petroleum ether, acetonitrile, methanol, ethanol, isopropanol, n-hexane, n-heptane, ethyl acetate, pyridine and ammonium hydroxide. Finally, the instrument also works with all combinatorial chemistry solvents and synthesis solids.
All three contain the same SPD140DDA concentrator unit. The SPD140DDA-230 is the standalone unit with SUMAX SPD upper magnetic assembly and PTFE tubing. The SPD140P1-230 is a Semi-Integrated System kit with UVS850DDA Universal Vacuum System and ANT100 post-trap. The SPD140P2-230 is a Component High Vacuum System kit with RVT450 cold trap, VLP80DDA high vacuum pump, DVG50 vacuum gauge and VPOF110 oil filter for maximum flexibility and high vacuum.
That depends on your solvents. Firstly, for volatile low-boiling solvents (DCM) and small quantities of DMSO you choose the UVS850DDA Universal Vacuum System (P1 kit). Secondly, for large volumes of high-boiling solvents (DMSO, DMF) you use RVT450 + VLP80DDA. Thirdly, for large volumes of low-boiling solvents (DCM) you choose RVT5105 + VLP80DDA. In addition, if you want to process all types of solvents, you combine RVT450 + RVT5105 + VLP80DDA.
Vacuum ramp control regulates the speed at which vacuum is built up in the chamber. As a result, you prevent bumping of your samples. You set the ramp at 5 levels: 5, 30, 40, 50 or 70 Torr/min. Subsequently, you choose step 1 (5 Torr/min) for difficult solvents such as DMSO or hard-to-dry combinations, and step 5 (70 Torr/min) for fast drying of simple non-aggressive solvents. Moreover, you combine this ramp control with a specific vacuum level for optimal results.
Yes, the SPD140DDA is specifically designed for DMSO. Firstly, the heated glass cover prevents DMSO condensation on the glass. In addition, Thermo offers dedicated system setups for DMSO. For large DMSO volumes, you choose the Component High Vacuum System (P2) with RVT450 + VLP80DDA. Alternatively, you choose the Low Vacuum System (LVS140DDA) with RVT450 + RVT5105 + OFP400 oil-free pump for oil-free DMSO processing. Finally, Preset 4 contains a pre-programmed DMSO mode (65°C, 100 mTorr, ramp 5).
The SPD140DDA offers 4 preset programs and 8 user-defined programs. The preset programs are: Water (45°C, 14 Torr, ramp 5), Low Boiling ACN/MEOH (45°C, 100 mTorr, ramp 5), HPLC (no heating, 10 Torr, ramp 5) and High Boiling Solvents (65°C, 100 mTorr, ramp 5) for acetic acid, isopropanol, toluene, DMSO and TFA. In addition, you configure 8 of your own programs for your specific workflows.
The SUMAX SPD is an upper magnetic assembly that is supplied and installed as standard. As a result, the system enables high-quality drive with magnetic coupling. Moreover, the maintenance is straightforward: every two weeks (depending on usage) you remove the assembly with a screwdriver, rinse it under tap water, dry it and reinstall it. This is essential for optimal performance during intensive use with aggressive solvents.
Yes, via the USB type A/B port you export live run data at a fixed baud rate of 115200. Every minute, you receive the live chamber temperature, remaining heat time, run time and vacuum value in CSV format. As a result, you easily meet GMP and GLP reporting requirements for pharmaceutical and biotech applications.
No, radiant heat should not be used with microplates. As a result, they may melt or deform. For microplate applications you switch off the RL On/Off button and use only chamber heat up to a maximum of 80°C.
230 VAC / 50 Hz, 3 amperes. The plug is a SCHUKO standard European plug and fits directly into Dutch wall sockets. The fuse is a 3 A, 250 VAC time-lag fuse.
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