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The Savant SpeedVac SPD210 high capacity vacuum concentrator from Thermo Scientific is a compact modular benchtop concentrator for drying non-aggressive organic solvents. As a result, you process up to 200 samples per run. Moreover, you combine the SPD210 with a separate refrigerated cold trap and vacuum pump of your choice. In this way, you build a setup that matches your lab.
Firstly, the SPD210 processes up to 200 × 1.5-2.0 mL microtubes per run with the RH200-12 rotor. In addition, the system accepts 192 × 1-dram glass vials, 48 × 50 mL conical tubes, 88 × 16 × 125 mm tubes, 50 × 20 mL scintillation vials and 8 × 100 mL pear-shaped flasks. Moreover, microplate rotors are available for shallow well and deep well plates. As a result, the SPD210 is suitable for laboratories processing large series in a compact footprint.
Firstly, the SPD210 is deliberately designed as a standalone concentrator unit. As a result, you choose which cold trap and which vacuum pump best matches your lab. Moreover, Thermo recommends two configurations. The first option is the Semi-Integrated System with UVS450 Universal Vacuum Source and ANT100 post-trap. The second option is the Component High Vacuum System with separate RVT450 cold trap, VLP120 vacuum pump, SCT120 chemical trap and DVG50 vacuum gauge. Consequently, you assemble a system that exactly matches your existing infrastructure.
Firstly, the SPD210 is designed for non-aggressive organic solvents. Typical solvents include methanol, acetonitrile, ethanol, isopropanol, n-butanol, isobutanol, n-propanol, n-hexane, n-heptane, pyridine, ammonium hydroxide and water. In addition, the system works with combinations of water+ACN+MeOH with low concentrations of acid (0.1% TFA). Therefore, the instrument is ideal for HPLC fractions and reversed-phase SPE eluent applications. However, for aggressive solvents such as DMSO, methylene chloride or strong acids and bases, you choose the SPD300DDA high capacity DDA variant.
Firstly, the control panel offers three modifiable factory programs. By default, these are set to Water (45°C, 2 hour heat time, 2 hour run time), Low Boiling ACN/MEOH (65°C, 2 hour heat time, 2 hour run time) and HPLC (no heating, 2 hour run time). In addition, you set the chamber temperature per program between 35°C and 65°C in 5°C increments. Alternatively, you select “no” for no heating at all. Moreover, the SPD210 works with two independent timers (heat time and run time). Each timer can be set from 1 minute to 9 hours 59 minutes, or to continuous (CCC) for the heat time.
Firstly, the SPD210 features a USB type A/B port that exports live run data to an external computer. Subsequently, the system sends the live chamber temperature, remaining heat time and remaining or elapsed run time every minute. Moreover, the data arrives in CSV format at a fixed baud rate of 115200. As a result, you easily meet GMP and GLP reporting requirements for pharmaceutical and biotech applications.
Firstly, the glass cover with safety interlock locks automatically during a run. Consequently, the cover opens only when the rotor has fully stopped and the vacuum has been released. In addition, the SPD210 features a hydraulic damper that lets the cover open and close smoothly. Finally, a Cover Lock Emergency Release Tool is supplied as standard for removing samples during a power failure.
Firstly, Thermo Scientific offers two complete kit options for the SPD210. The first is the SPD210P1-230 kit with RVT5105 ultra-low temperature vapor trap (-104°C), vacuum pump, RH200-12 rotor (200 × 1.5 mL), digital vacuum gauge, universal tubing, chemical trap, disposable cartridge, glass condensation flask and CryoCool heat transfer fluid. Secondly, the SPD210P2-230 kit with UVS450 Universal Vacuum Source (-55°C), tubing kit, CryoCool and RH200-12 rotor.
Firstly, Thermo offers several practical tips for the highest drying speed. To begin, you use glass tubes and vials instead of plastic, because glass conducts heat better. In addition, you preheat the SpeedVac chamber and rotor before loading samples. Moreover, rotors with metal tube carriers (RH12-20, RH8-18) help with faster heat transfer. Finally, you prewash plastic tubes with methanol to remove materials that inhibit evaporation of aqueous samples.
Firstly, the SPD210 is available in three configurations. The first is the standalone concentrator unit with power cord and Cover Lock Emergency Release Tool. Secondly, the complete SPD210P1-230 kit for HPLC and SPE applications with RVT5105 vapor trap, vacuum pump, rotor, vacuum gauge and accessories. Thirdly, the SPD210P2-230 kit with UVS450 Universal Vacuum Source and RH200-12 rotor. In addition, for optimal vacuum pump maintenance with aggressive solvents, Thermo recommends a VPOF110 oil filter.
Firstly, the SPD210 is used in life sciences, biotech, organic chemistry, drug discovery, peptide synthesis and the pharmaceutical industry. Typical applications include HPLC fractions with water and 0.1% TFA, reversed-phase SPE eluent processing, protein and peptide concentration in large series, DNA/RNA precipitation and metabolite research. Would you like advice on the right SpeedVac for your application? Contact us and our product specialists will be glad to help.
| Property | Value |
|---|---|
| Model | SPD210-230 |
| System type | Modular high capacity (concentrator unit, cold trap and pump separate) |
| Capacity | Up to 200 × 1.5-2.0 mL microtubes (RH200-12 rotor), or 48 × 50 mL conical tubes (RH48-50U) |
| Dimensions (W × D × H) | 48 × 66 × 46 cm |
| Weight | 53 kg |
| Chamber material | TEFLON-coated chemical resistant aluminum casting |
| Vapor path materials | Polypropylene and Teflon |
| Cover | Glass cover with safety interlock |
| Lid-stay mechanism | Hydraulic damper |
| Cover lock emergency release | Cover Lock Emergency Release Tool (included as standard) |
| Temperature range | 35-65°C in 5°C increments, or “no” for no heating |
| Pre-heat function | 45°C |
| Bleeder valve | Automatic (for unattended start/stop) |
| Programs | 3 modifiable programs (Water, Low Boiling ACN/MEOH, HPLC) |
| Timer range | 2 independent timers: 1 minute to 9 hours 59 minutes, or continuous (CCC) for heat time |
| Operating modes | Auto Run, Manual Run, Pre-heat |
| Data export | USB type A/B port, 115200 baud, CSV format (temperature, heat time, run time) |
| Power supply | 230 VAC / 50 Hz, 6 amperes |
| Fuse | 6 A, 250 VAC, Time-lag |
| Induction motor | Maintenance-free |
| Compatible solvents | Water, acetonitrile, methanol, ethanol, isopropanol, n-butanol, isobutanol, n-propanol, n-hexane, n-heptane, pyridine, ammonium hydroxide, water+ACN+MeOH+0.1% TFA |
| Not suitable for | Aggressive solvents (DMSO, methylene chloride, strong acids and bases — choose SPD300DDA) |
| Rotor blocks | Compatible with FPR-4A 4-position rotor (rotor blocks available separately) |
| Audible notifications | Yes (5 beeps startup, 1 beep run start, 3 beeps stop, error tones) |
| Maximum altitude | 2000 meters above sea level |
| Ambient temperature | 17°C to 32°C |
| Humidity | 20% to 80% non-condensing |
| Required ventilation space | 10 cm (4 inch) on all sides, 48 cm (19 inch) overhead for cover opening |
| Included (standard) | SPD210 concentrator, Cover Lock Emergency Release Tool, power cord |
| SPD210P1 kit additions | RVT5105 (-104°C) vapor trap + vacuum pump + RH200-12 rotor + DVG50 digital vacuum gauge + universal tubing + SCT120 chemical trap + DC120A cartridge + GF4000 glass condensation flask + SCC1 CryoCool (1L) |
| SPD210P2 kit additions | UVS450 Universal Vacuum Source (-55°C) + tubing kit + SCC1 CryoCool (1L) + RH200-12 rotor |
| Certification | UL listed (US/Canada), CE |
Modular high capacity SpeedVac vacuum concentrator for non-aggressive organic solvents. Compact benchtop concentrator unit for up to 200 × 1.5 mL microtubes per run. Glass cover with safety interlock, TEFLON-coated aluminum chamber, 3 modifiable programs and USB data export. Specifically optimized for HPLC fractions with water+0.1% TFA and reversed-phase SPE. Available as standalone unit, P1 kit with RVT5105 (-104°C) or P2 kit with UVS450 (-55°C).
The SPD210 is used for high-throughput concentration and drying of samples in non-aggressive organic solvents. Typical applications include HPLC fractions with water and 0.1% TFA, reversed-phase SPE eluent processing, protein and peptide concentration, DNA/RNA precipitation and metabolite research in large series.
Both are high capacity SpeedVac models with the same capacity of 200 microtubes per run. However, the main difference is the modular design. The SPD2030 is a fully integrated system with built-in cold trap, pump and vacuum gauge. By contrast, the SPD210 is modular, which means you combine the concentrator unit with a separate cold trap and vacuum pump. As a result, the SPD210 offers more flexibility for applications requiring specific cold trap temperatures, such as the -104°C RVT5105 for aggressive solvents.
Both are high capacity modular SpeedVacs of comparable size. However, the main difference is chemical resistance. The SPD210 is intended for non-aggressive organic solvents such as methanol, acetonitrile, ethanol and water. By contrast, the SPD300DDA is industrial strength and resistant to aggressive solvents such as DMSO, methylene chloride, TFA and strong acids and bases. Therefore, for combinatorial chemistry or aggressive applications you choose the SPD300DDA.
The SPD210 is suitable for non-aggressive organic solvents. For example, water, acetonitrile, methanol, ethanol, isopropanol, n-butanol, isobutanol, n-propanol, n-hexane, n-heptane, pyridine and ammonium hydroxide. In addition, the system works with combinations of water+ACN+MeOH with low concentrations of acid (0.1% TFA). However, for aggressive solvents such as DMSO, methylene chloride, strong acids or bases, you choose the SPD300DDA.
All three contain the same SPD210 concentrator unit. The SPD210-230 is the standalone unit with Cover Lock Emergency Release Tool. The SPD210P1-230 is a complete kit for HPLC and SPE applications with RVT5105 ultra-low temperature vapor trap (-104°C), vacuum pump, RH200-12 rotor, digital vacuum gauge, universal tubing, chemical trap, disposable cartridge, glass condensation flask and CryoCool. The SPD210P2-230 is a kit with UVS450 Universal Vacuum Source (-55°C), tubing kit, CryoCool and RH200-12 rotor.
You choose between two recommended options. Firstly, the RVT5105 ultra-low temperature vapor trap (-104°C), suitable for lyophilization and low-boiling solvents. This is included as standard in the SPD210P1 kit. Secondly, the UVS450 Universal Vacuum Source with -55°C cold trap, which is included in the SPD210P2 kit. Alternatively, you choose a component setup with the RVT450 (-50°C) plus a separate VLP120 vacuum pump.
Depending on the rotor, the SPD210 processes up to 200 × 1.5-2.0 mL microtubes (RH200-12), 192 × 1-dram glass vials (RH192-15), 48 × 50 mL conical tubes (RH48-50U), 88 × 16 × 125 mm tubes (RH88-16-125), 50 × 20 mL scintillation vials (RH50-28-60) or 8 × 100 mL pear-shaped flasks (RH8-200). Furthermore, microplate rotors are available for shallow well (12 plates) and deep well (4 plates) applications.
Yes, via the USB type A/B port you export live run data at a fixed baud rate of 115200. Every minute, you receive the live chamber temperature, remaining heat time and run time in CSV format. As a result, you easily meet GMP and GLP reporting requirements for pharmaceutical and biotech applications.
The SPD210 is supplied with three modifiable factory programs. Firstly, Water (45°C, 2 hour heat time, 2 hour run time). Secondly, Low Boiling ACN/MEOH (65°C, 2 hour heat time, 2 hour run time). Thirdly, HPLC (no heating, 2 hour run time). In addition, you customize and save each program by holding the Program button for 3 seconds.
Thermo provides several tips for faster drying. Firstly, you use glass tubes and vials instead of plastic. Secondly, you preheat the SpeedVac chamber and rotor before loading samples. In addition, rotors with metal tube carriers (such as RH12-20 or RH8-18) help with faster heat transfer. Finally, you prewash plastic tubes with methanol to remove materials that inhibit evaporation of aqueous samples.
230 VAC / 50 Hz, 6 amperes. The plug is a SCHUKO standard European plug and fits directly into Dutch wall sockets. The fuse is a 6 A, 250 VAC time-lag fuse. Note that the SPD210 draws more current than the medium capacity SpeedVacs (3A for SPD120/SPD140DDA), so make sure you have a suitable outlet.
The SPD210 operates from 35°C to 65°C in 5°C increments, or “no” for no heating. This is slightly lower than the medium capacity SpeedVacs which go up to 80°C. The lower maximum temperature is optimized for protecting biological samples during long runs with large sample volumes.
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