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The Savant SpeedVac SPD300DDA modular large capacity vacuum concentrator from Thermo Scientific is an industrial strength benchtop concentrator for drying highly aggressive solvents in large volumes. As a result, you process DMSO, methylene chloride (DCM), TFA, tetrahydrofuran (THF), strong acids and strong bases. Moreover, this model combines the chemical resistance of the SPD140DDA with the high-capacity throughput of the SPD210.
Firstly, the SPD300DDA is the heaviest and largest SpeedVac in the Thermo Scientific range. As a result, you process both large sample volumes and highly aggressive solvents in one instrument. For example, DMSO, DMF, methylene chloride, TFA, strong acids and strong bases. Moreover, this is the only large capacity model recommended by Thermo for solid-phase extractions, drying lipid extracts, flash chromatography fractions and solid-phase synthesis cleavage solutions.
Firstly, a distinguishing feature is the FPR-4A 4-Place Aluminum Universal Plate Rotor. With this rotor, you place 4 carriers with diverse sample formats per run. Subsequently, you choose from three carrier types: UPC-1 (single-shelf for rotor blocks), UPC-2 (double-shelf for deepwell plates) and UPC-5 (5-shelf for shallow well microplates). As a result, you process microcentrifuge tubes, vials, conical tubes, pear-shaped flasks and microplates in one instrument. Finally, you order rotor blocks separately for the FPR-4A to expand your configuration further.
Firstly, the SPD300DDA features 4 built-in chamber radiant lamps, two more than the SPD140DDA. As a result, evaporation is significantly accelerated. Moreover, these lamps radiate heat directly onto the samples in the Universal Rotor. In addition, the heated glass cover adds extra radiant heat. Finally, the heated cover prevents condensation of DMSO on the glass, which keeps drying times consistent.
Firstly, the SPD300DDA combines several premium components for maximum resistance. To begin, the system contains a rugged stainless steel magnetic drive, lubricated with acid-resistant grease. In addition, the unit contains acid-resistant TEFLON bearings. Moreover, all components in the vapor path are made of PTFE or PTFE-coated materials. Finally, the dual valve manifold ensures that solvent vapor has minimal contact with other parts. In this way, the instrument retains its integrity during intensive use.
Firstly, a specific improvement over the SPD140DDA is the enlarged vacuum port. As a result, the cross-section of the vapor path is increased. Subsequently, vapor flows more efficiently out of the chamber to the cold trap. In addition, this reduces the risk of bumping during fast vacuum buildup. In this way, the SPD300DDA optimizes drying times even with large sample volumes.
Firstly, the vacuum ramp control regulates the speed at which vacuum is built up. You set this at 5 levels: 5, 30, 40, 50 or 70 Torr/min. As a result, you prevent bumping with low-boiling solvents. In addition, the dual valve manifold provides a dedicated bleed port that guarantees unidirectional vapor flow. Moreover, this port purges the bearings with fresh air. Finally, you combine this control with the vacuum level setting from 20 to 0.1 Torr in 0.1 increments.
Firstly, the SPD300DDA offers 4 preset programs plus 8 user-defined programs. The preset programs are: Water (45°C, 14 Torr, ramp 5), Low Boiling ACN/MEOH (45°C, 100 mTorr, ramp 5), HPLC (no heating, 10 Torr, ramp 5) and High Boiling Solvents (65°C, 100 mTorr, ramp 5) for acetic acid, isopropanol, toluene, DMSO and TFA. In addition, you configure 8 of your own programs for your specific workflows.
Firstly, the SPD300DDA accepts the broadest range of solvents of all SpeedVacs. For example, DMSO, DMF, methylene chloride (DCM), tetrahydrofuran (THF), trifluoroacetic acid (TFA), HCl, strong acids and bases. In addition, the system works with benzene, toluene, nitrobenzene, pentane, acetone, chloroform, cyclohexane, ethyl ether, acetonitrile, methanol, ethanol, isopropanol, n-hexane, n-heptane, ethyl acetate, pyridine and ammonium hydroxide. Finally, the instrument is approved for combinatorial chemistry solvents and synthesis solids.
Firstly, Thermo Scientific recommends four system configurations depending on your solvents. The first option is the UVS850DDA Universal Vacuum System for volatile low-boiling solvents (DCM) and small quantities of DMSO and DMF. Secondly, the RVT450 + VLP80DDA setup for large volumes of high-boiling solvents such as DMSO and DMF. Thirdly, the RVT5105 + VLP80DDA setup for large volumes of low-boiling solvents. Finally, for all types of solvents you choose the complete combination RVT450 + RVT5105 + VLP80DDA.
Firstly, the SPD300DDA exports live run data every minute via the USB type A/B port. Subsequently, you receive chamber temperature, remaining heat time, run time and vacuum value in CSV format at 115200 baud. As a result, you easily meet GMP and GLP reporting requirements for pharmaceutical and biotech applications.
Firstly, the SPD300DDA is supplied as standard with an attached SUMAX400 upper magnetic assembly. This assembly is larger and heavier than the SUMAX SPD in the SPD140DDA. As a result, the system processes larger sample loads without performance loss. Moreover, the maintenance is straightforward: every two weeks you remove the assembly with a screwdriver, rinse it under tap water, dry it and reinstall it.
Firstly, the SPD300DDA is available in four configurations for diverse needs. The first is SPD300DDA-230 as standalone unit. Secondly, SPD300DDAA-230 as Integrated System including FPR-4A Universal Rotor and UPC-1 carriers. Thirdly, SPD300P1-230 as complete kit with RVT5105 (-105°C) ultra-low temperature vapor trap, VLP120 vacuum pump, FPR-4A, UPC-1, CryoCool, glass condensation flask, vacuum tubing and pump oil. Finally, SPD300P2-230 as Semi-Integrated kit with UVS850DDA Universal Vacuum System.
Firstly, the SPD300DDA is used for combinatorial chemistry, medicinal chemistry, drug discovery, peptide synthesis, organic synthesis, lipid extraction and the pharmaceutical industry. Typical applications include solid-phase extractions, drying lipid extracts, flash chromatography fractions, solid-phase synthesis cleavage, protein hydrolyzates, evaporating synthesis solids and HPLC fractions with aggressive solvents. Would you like advice on the right SpeedVac for your application? Contact us and our product specialists will be glad to help.
| Property | Value |
|---|---|
| Model | SPD300DDA-230 |
| System type | Modular DDA (Dual Direct Aggressive) large capacity industrial strength |
| Capacity | Up to 200 × 1.5-2.0 mL microtubes (RH200-12), 192 × 1-dram vials (RH192-15), 48 × 50 mL conical tubes (RH48-50U), 8 × 100 mL pear-shaped flasks (RH8-200), 12 shallow well or 4 deepwell microplates |
| Rotor | FPR-4A 4-Place Aluminum Universal Plate Rotor with 4 carriers |
| Carrier options | UPC-1 (single-shelf for rotor blocks), UPC-2 (double-shelf for deepwell plates), UPC-5 (5-shelf for shallow well plates) |
| Dimensions (W × D × H) | 48 × 66 × 46 cm |
| Weight | 53 kg |
| Chamber material | PTFE (TEFLON)-coated chemical resistant aluminum casting with 4 built-in radiant lamps |
| Vapor path materials | PTFE and PTFE-coated materials (exclusively in vapor path) |
| Bearings | Acid-resistant TEFLON bearings |
| Magnetic drive | Rugged stainless steel with acid-resistant grease |
| Magnetic assembly | SUMAX400 upper magnetic assembly (included as standard) |
| Chamber seal | Viton rubber |
| Fittings | Polypropylene |
| Cover | Heated glass safety cover with safety interlock (prevents DMSO condensation) |
| Radiant lamps | 4 built into chamber + heated cover |
| Dual valve manifold | Yes (for minimal vapor exposure) |
| Enlarged vacuum port | Yes (for efficient vapor transport) |
| Dedicated bleed port | Yes (for unidirectional vapor flow and bearing purge) |
| Lid-stay mechanism | Yes |
| Cover lock emergency release | Cover Lock Emergency Release Tool (included as standard) |
| Temperature range | 35-80°C in 5°C increments, or “no” for no heating |
| Pre-heat function | 45°C |
| Vacuum level setting | 20 to 0.1 Torr in 0.1 increments |
| Vacuum ramp setting | 5 levels: 5, 30, 40, 50 or 70 Torr/min |
| Vacuum gauge | Built-in digital vacuum gauge (Torr and milliTorr) |
| Programs | 4 preset (Water, Low Boiling ACN/MEOH, HPLC, High Boiling Solvents) + 8 user-defined (modifiable and storable) |
| Timer range | 2 independent timers: 1 minute to 9 hours 59 minutes, or continuous (CCC) for heat time |
| Operating modes | Auto Run, Manual Run, Pre-heat, RL On/Off, Vacuum Type (Level/Ramp) |
| Data export | USB type A/B port, 115200 baud, CSV format (temperature, heat time, run time, vacuum pressure) |
| Power supply | 230 VAC / 50 Hz, 6 amperes |
| Fuse | 6 A, 250 VAC, Time-lag |
| Plug | SCHUKO CEE 7/7 (Euro plug) |
| Rotor spin speed | 1040 rpm (50 Hz) |
| Induction motor | Maintenance-free |
| Compatible solvents | DMSO, DMF, DCM, THF, TFA, HCl, acetone, acetic acid, ammonium hydroxide, benzene, butanol, chloroform, cyclohexane, ethyl acetate, ethanol, ethyl ether, n-hexane, n-heptane, isopropanol, isobutanol, methanol, methylene chloride, nitrobenzene, pentane, petroleum ether, n-propanol, pyridine, toluene, and all non-aggressive solvents |
| Specific approval | Combinatorial chemistry |
| P1 kit cold trap | RVT5105 (-105°C) + VLP120 vacuum pump |
| P2 kit cold trap | UVS850DDA Universal Vacuum System (integrated cold trap + oil-free pump) |
| SUMAX400 maintenance | Every 2 weeks (depending on usage) |
| Audible notifications | Yes (5 beeps startup, 1 beep run start, 3 beeps stop, error tones) |
| Certification | UL listed (US/Canada), CE |
| Required ventilation space | 8 cm on all sides, 46 cm overhead for cover opening |
| Included (standard SPD300DDA-230) | SPD300DDA concentrator with attached SUMAX400, PTFE hose assembly (1.5″ I.D.), PTFE tubing (1/2″ × 120 cm), GF4000 4L glass condensation flask, flask cap assembly, 2 NW50 clamps, 2 NW50 centering rings, insulation cover, Cover Lock Emergency Release Tool, power cord |
Industrial strength large capacity SpeedVac vacuum concentrator for highly aggressive solvents in large volumes. Resistant to DMSO, methylene chloride, THF, TFA, strong acids and bases thanks to stainless steel magnetic drive and PTFE vapor path. Heavy-duty FPR-4A Universal Rotor with 4 carriers for microplates, vials, tubes and flasks. 4 built-in radiant lamps, vacuum ramp control and 12 programs. Available as standalone unit, Integrated System (DDAA), P1 kit (RVT5105) or P2 kit (UVS850DDA).
The SPD300DDA is used for high-throughput concentration and drying of samples in highly aggressive solvents. Typical applications include combinatorial chemistry, solid-phase extractions, drying lipid extracts, flash chromatography fractions, solid-phase synthesis cleavage, protein hydrolyzates, peptide synthesis and HPLC fractions with TFA, DMSO, DCM, THF or strong acids and bases.
Both are modular DDA SpeedVacs for aggressive solvents with the same stainless steel magnetic drive and acid-resistant TEFLON bearings. However, the main difference is the capacity and the heating system. Firstly, the SPD300DDA is considerably larger (48 × 66 × 46 cm versus 36 × 46 × 36 cm) and heavier (53 kg versus 28 kg). Secondly, the SPD300DDA features 4 built-in radiant lamps compared to 2 on the SPD140DDA. Moreover, the SPD300DDA uses the heavy-duty FPR-4A Universal Rotor with 4 carriers for maximum flexibility. Finally, the SPD300DDA supports tetrahydrofuran (THF), which is not in the SPD140DDA solvent list.
Both are modular large capacity SpeedVacs of comparable size (48 × 66 × 46 cm, 53 kg). However, the main difference is chemical resistance. The SPD210 is intended for non-aggressive organic solvents such as methanol, acetonitrile, ethanol and water. By contrast, the SPD300DDA is industrial strength and resistant to aggressive solvents such as DMSO, DCM, THF, TFA and strong acids and bases. In addition, the SPD300DDA offers 12 programs compared to 3 on the SPD210, vacuum ramp control and the heavy-duty FPR-4A Universal Rotor.
The SPD300DDA processes by far the broadest range of solvents of all SpeedVacs. For example, DMSO, DMF, methylene chloride (DCM), tetrahydrofuran (THF), trifluoroacetic acid (TFA), HCl, strong acids and bases. In addition, the system accepts benzene, toluene, nitrobenzene, pentane, acetone, chloroform, cyclohexane, ethyl ether, petroleum ether, acetonitrile, methanol, ethanol, isopropanol, n-hexane, n-heptane, ethyl acetate, pyridine and ammonium hydroxide. Finally, the instrument is approved for combinatorial chemistry solvents and synthesis solids.
All four contain the same SPD300DDA concentrator unit. The SPD300DDA-230 is the standalone unit. The SPD300DDAA-230 is the Integrated System including FPR-4A Universal Rotor and UPC-1 carriers. The SPD300P1-230 is a complete kit for aggressive solvents with RVT5105 (-105°C) ultra-low temperature vapor trap, VLP120 vacuum pump, FPR-4A, UPC-1, glass condensation flask, tubing and pump oil. The SPD300P2-230 is a Semi-Integrated kit with UVS850DDA Universal Vacuum System (integrated cold trap plus oil-free pump).
That depends on your solvents. Firstly, for volatile low-boiling solvents (DCM) and small quantities of DMSO you choose the UVS850DDA Universal Vacuum System (P2 kit). Secondly, for large volumes of high-boiling solvents (DMSO, DMF) you use RVT450 + VLP80DDA. Thirdly, for large volumes of low-boiling solvents (DCM) you choose RVT5105 + VLP80DDA. Finally, if you want to process all types of solvents, you combine RVT450 + RVT5105 + VLP80DDA.
The FPR-4A is a heavy-duty 4-Place Aluminum Universal Plate Rotor that is supplied as standard with the SPD300DDAA, P1 and P2 configurations. As a result, you place 4 carriers with diverse sample formats per run. Subsequently, you choose from three carrier types: UPC-1 (single-shelf for rotor blocks), UPC-2 (double-shelf for deepwell plates) or UPC-5 (5-shelf for shallow well microplates). Moreover, the FPR-4A is optionally expandable with rotor blocks for specific tube and vial formats.
Vacuum ramp control regulates the speed at which vacuum is built up in the chamber. As a result, you prevent bumping of your samples. You set the ramp at 5 levels: 5, 30, 40, 50 or 70 Torr/min. Subsequently, you choose step 1 (5 Torr/min) for difficult solvents such as DMSO and step 5 (70 Torr/min) for fast drying of simple non-aggressive solvents. Moreover, you combine this ramp control with a specific vacuum level for optimal results.
Yes, the SPD300DDA is specifically designed for DMSO. Firstly, the heated glass cover prevents DMSO condensation on the glass. In addition, Thermo offers dedicated system setups for DMSO. For large DMSO volumes you choose the RVT450 + VLP80DDA setup. Moreover, Preset 4 contains a pre-programmed DMSO mode (65°C, 100 mTorr, ramp 5). Finally, the stainless steel magnetic drive with acid-resistant grease ensures long-term reliable use with DMSO.
The SPD300DDA offers 4 preset programs and 8 user-defined programs. The preset programs are: Water (45°C, 14 Torr, ramp 5), Low Boiling ACN/MEOH (45°C, 100 mTorr, ramp 5), HPLC (no heating, 10 Torr, ramp 5) and High Boiling Solvents (65°C, 100 mTorr, ramp 5) for acetic acid, isopropanol, toluene, DMSO and TFA. In addition, you configure 8 of your own programs for your specific workflows.
The SUMAX400 is an upper magnetic assembly that is supplied and installed as standard. It is larger and heavier than the SUMAX SPD in the SPD140DDA, designed for the larger sample loads of the SPD300DDA. Moreover, the maintenance is straightforward: every two weeks (depending on usage) you remove the assembly with a screwdriver, rinse it under tap water, dry it and reinstall it. This is essential for optimal performance during intensive use with aggressive solvents.
Yes, via the USB type A/B port you export live run data at a fixed baud rate of 115200. Every minute, you receive the live chamber temperature, remaining heat time, run time and vacuum value in CSV format. As a result, you easily meet GMP and GLP reporting requirements for pharmaceutical and biotech applications.
230 VAC / 50 Hz, 6 amperes. The plug is a SCHUKO CEE 7/7 standard European plug and fits directly into Dutch wall sockets. The fuse is a 6 A, 250 VAC time-lag fuse. Note that the SPD300DDA draws more current than the medium capacity SpeedVacs (3A for SPD120/SPD140DDA), so make sure you have a suitable outlet.
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